Peptide Synthesis
TESTING
A peptide consists of two or more amino acids linked by an amide bond, to form a chain of amino acids typically 2 – 70 amino-acids long. Peptides are distinguished from proteins by not requiring to be folded for biological activity. Peptides occur endogenously as peptide hormones, such as angiotension, LHRH, enkephalin, and as toxins in plants and animals. Peptides are of great interest as lead compounds for drug discovery and as drugs in their own right. They also find applications in vaccines, biomaterials, histological probes and are used in large numbers as antigens to generate antibodies.
Peptides are synthesized chemically either in solution or on a solid phase. The process involves directed and selective formation of an amide bond between an N-protected amino acid and an amino acid bearing a free amino group and protected carboxylic acid. In solid phase synthesis, the carboxyl protecting group is linked to a polymer support. Following bond formation, the amino-protecting group of the dipeptide is removed, and the next N-protected amino-acid is coupled.
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We offer an extensive range of amino acids, resins, and reagents of unparalleled quality, including Novabiochem®, for peptide synthesis, high-throughput organic chemistry, labeling peptides, and custom manufactured products.
Our stable and tolerable NHC ligands and complexes can be used as efficient ancillary ligands to keep your work flowing in organometallic catalysis and catalysis chemistry research.
Our portfolio of click chemistry reagents includes a variety of azides, alkynes, catalysts, and ligands to accelerate your progress in chemical biology, polymer chemistry, bioconjugation, and drug discovery.
Our portfolio of linkers and crosslinkers provide structural stability and reliability in protein-protein, protein-peptide, and peptide/protein-small molecule interactions for all your bioconjugation needs.
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