- Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia.
Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia.
Disease models & mechanisms (2017-01-10)
Claudio Nardiello, Ivana Mižíková, Diogo M Silva, Jordi Ruiz-Camp, Konstantin Mayer, István Vadász, Susanne Herold, Werner Seeger, Rory E Morty
PMID28067624
ABSTRACT
Progress in developing new therapies for bronchopulmonary dysplasia (BPD) is sometimes complicated by the lack of a standardised animal model. Our objective was to develop a robust hyperoxia-based mouse model of BPD that recapitulated the pathological perturbations to lung structure noted in infants with BPD. Newborn mouse pups were exposed to a varying fraction of oxygen in the inspired air (FiO