- Rapid formation of N-Glycopeptides via Cu(II)-promoted glycosylative ligation.
Rapid formation of N-Glycopeptides via Cu(II)-promoted glycosylative ligation.
Organic letters (2013-01-26)
Ryan Joseph, Frank Brock Dyer, Philip Garner
PMID23346888
ABSTRACT
Herein is described the chemoselective Cu(II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines; (2) it is remarkably fast, going to completion in under 30 min; and (3) it produces glycopeptides without attendant aspartimide formation.
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