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  • Autoradiography in mice of tritiated 2-(2-furyl)benzimidazole and melanin-binding in vitro.

Autoradiography in mice of tritiated 2-(2-furyl)benzimidazole and melanin-binding in vitro.

Toxicology letters (1983-07-01)
A Frank, B Larsson, S Fabiansson
ABSTRACT

The distribution of tritiated 2-(2-furyl)benzimidazole ([3H]FB) in male and pregnant albino mice and male pigmented mice was studied by whole-body autoradiography. The most notable finding was the accumulation of radioactivity in the melanin-containing tissues of the eye, the inner ear and the hair follicles. An additional study in vitro on isolated bovine-eye melanin showed a substantial binding of [3H]FB to the melanin. The general distribution was characterized by a rapid excretion pattern, except for uptake in the thyroid and nasal mucosa. Transfer to fetuses was significant and the fetal distribution was dominated by excretion.

MATERIALS
Product Number
Brand
Product Description

Supelco
Fuberidazole, PESTANAL®, analytical standard