- Improved copper(I)-NHC catalytic efficiency on huisgen reaction by addition of aromatic nitrogen donors.
Improved copper(I)-NHC catalytic efficiency on huisgen reaction by addition of aromatic nitrogen donors.
A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4-DMAP (4-dimethylaminopyridine) increases copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) catalytic activity of [CuCl(SIMes)] at a large range of temperatures in such a way that efficient catalysis can safely take place in hydro-alcoholic solvents (see scheme).