Skip to Content
Merck
HomeProductsProtein BiologyProteins, Enzymes & Small MoleculesStructural Genomics Consortium

Structural Genomics Consortium

Target validation using SGC chemical probes

The SGC is a not-for-profit organization that partners public and private entities with the goal of conducting open-access research with relevance to drug discovery, placing a primary focus on elucidating the 3D structures of human protein and human parasite protein targets. Approximately 200 scientists from the Universities of Oxford and Toronto and nine pharmaceutical companies work to achieve this goal, making the structures, reagents and methods available to the public to facilitate further research on protein targets.

Chemical Probes

In your research, it is essential to ensure that your target is the right target. We have partnered with the Structural Genomics Consortium (SGC) to provide highly characterized, novel chemical probes for researching clinically relevant protein targets. These probes, developed and characterized by the SGC, meet strict criteria for potency, selectivity, and cell-permeability in order to be used as essential tools in preclinical target validation. Originally focusing on proteins involved in epigenetic control, including well-studied targets such as the bromodomain-containing BET family of proteins and histone methyltransferase EZH2, the SGC has expanded to include chemical probes for other research areas, including kinases, serine proteases and other protein families.

Target Validation Using Chemical Probes

Backed by full characterization data from the SGC and the consistency and high quality of our Bioactive Small Molecule portfolio, SGC chemical probes allow you to validate your target with confidence. Explore the full offering of SGC chemical probes, including probes for bromodomains, methyltransferases, kinases, and other epigenetic targets.

Related Product Categories
Pfizer Compounds
Pfizer research compounds in support of your neuroscience, gene regulation, ADME/Tox, immunology, ion channels and lipid signaling, apoptosis and cell cycle, cytokines and growth factor drug discovery workflows.
Albumins and Transport Proteins
Albumin is used in vitro to bind, sequester and stabilize a range of important small molecules and proteins. We provide bovine and human serum albumins and transport protein reagents for diverse applications, including cell culture, protein quantitation, and antibody-related studies.
Hormones
Boost cell growth using essential hormones: insulin, dexamethasone, β-Estradiol, and others. Elevate your cell culture success.
Supplements for Cell Culture
Cell culture supplements enable the customization of media with defined characteristics to support specific applications and serum-free culture needs. Our culture-grade supplements include ITS formulations, amino acids, vitamins, antibiotics, and reagents qualified for hybridoma and insect cell culture.
Sera
Origin-certified, quality-controlled cell culture sera include FBS, other bovine sera, human serum, and sera from diverse animal species, rigorously screened for contaminants and performance-tested in culture.
Human Serum for Cell Culture
Human serum is used to culture human cells and is available as plasma-derived AB human serum, clotted whole blood AB human serum, heat inactivated preparations, and complement-depleted preparations.
Fetal Bovine Serum (FBS)
FBS, or fetal bovine serum (also called FCS) is one of the most important supplements for mammalian cell culture. Choose FBS grade based on documentation requirements and application specificity.
Sera (Other)
Although FBS is the most common serum variety used for cell culture, adult and newborn bovine serum and sera from other species are alternatives for cell culture supplementation.
Related Applications
Mammalian Cell Culture
Applications, principles, and methods for in vitro mammalian cell culture including links to articles, protocols, and videos for proper aseptic technique, passaging and subculturing, and culture media considerations.
Primary Cell Culture
Primary cells isolated directly from human and animal sources maintain physiological relevance of the tissues from which they are derived, and are used for ADME/Tox screening. Find applications and methods for culturing mammalian primary cells in vitro.
Stem Cell Culture
An overview of different stem cell types, stem cell culture basics and stem cell applications in basic research and clinical research applications, such as tissue regeneration, genetic diseases and cancer.
Plant Tissue Culture
Plant cell and tissue culture in commercial plant production, conservation, and plant research. Meristem culture, virus-free plant propagation, protoplast and haploid plant production.
3D Cell Culture
Applications, principles, and techniques for three-dimensional (3D) cell culture. Includes techniques and descriptions of scaffold and scaffold-free methods matrices for the culture of complex in vitro models including organoids and spheroids.
Microbial Cell Culture
An overview of microbiological cell culture and its applications in molecular biology, cloning, and recombinant protein expression as well as cultivation for the isolation, differentiation, and identification of disease-causing microbes in clinical researc
Cell Growth & Maintenance
A synopsis of the conditions, media, nutrients, cultureware, and environments required for successful propagation of mammalian and yeast cells. Nutrient reagents, sterile technique and filtration, and requirements for 2D, 3D, and suspension cultures are described.
Bacteriology
An overview of the science and practice of bacteriology in clinical diagnostics. Learn more about the application of standard and special stains for microscopic analysis.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?