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Key Documents

SAB1302240

Sigma-Aldrich

ANTI-MOUSE NLRP6 (CENTER) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

LRR and PYD domains-containing protein 6, NACHT, Nalp6, Nlrp6, Pypaf5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

97402 Da

species reactivity

mouse

technique(s)

western blot: 1:1000

UniProt accession no.

Q91WS2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Nlrp6(101613)

General description

NLR family, pyrin domain containing 6 (NLRP6) maybe part of the inflammasome. It belongs to the Nod-like receptor family and is expressed in intestinal epithelial cells.

Biochem/physiol Actions

NLR family, pyrin domain containing 6 (NLRP6) has a role in innate immunity. It also maintains intestinal homeostasis by modulating autophagy and mucus secretion. Loss of NLRP6 has been shown to hinder the production of interleukin-18 (IL-18) and enhance susceptibility to epithelial-induced injury in rats.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury.
Seregin SS
Mucosal Immunology (2017)
NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila.
Seregin SS
Cellular Reprogramming (2017)
Pierre-Gregoire Coulon et al.
Frontiers in immunology, 10, 1631-1631 (2019-08-02)
The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an
Qifeng Deng et al.
Redox biology, 49, 102217-102217 (2021-12-24)
Maintaining host iron homeostasis is an essential component of nutritional immunity responsible for sequestrating iron from pathogens and controlling infection. Nucleotide-oligomerization domain-like receptors (NLRs) contribute to cytoplasmic sensing and antimicrobial response orchestration. However, it remains unknown whether and how NLRs
Bart Tummers et al.
Immunity, 52(6), 994-1006 (2020-05-20)
Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and lymphoproliferative (LPR) disease in mice result from abrogated CD95-induced apoptosis. Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the roles of caspase-8 in

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