Skip to Content
Merck

ERCC5

excision repair cross-complementing rodent repair deficiency, complementation group 5

Synonyms:
COFS3, ERCM2, UVDR, XPG, XPGC
Species:
UniProtKB ID:
Gene ID:
  • Human(2073) Summary: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]
  • Mouse(22592) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Rat(301382) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • domestic guinea pig(100734193) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • naked mole-rat(101723410) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • sheep(101114031) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Domestic Rabbit(100338146) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Zebrafish(541502) excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
  • cow(509602) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Horse(100063431) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • domestic cat(101085685) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • dog(485540) excision repair cross-complementing rodent repair deficiency, complementation group 5
  • chicken(428019) excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ERCC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-XPG (C-terminal) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-ERCC5 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
Anti-ERCC5 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rabbit, rat
Application
western blot
Anti-ERCC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ercc5,
Species
mouse
MISSION® esiRNA, targeting human ERCC5,
Species
human