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The catalytic cross-coupling of unactivated arenes.

Science (New York, N.Y.) (2007-05-26)
David R Stuart, Keith Fagnou
ZUSAMMENFASSUNG

The industrially important coupling of aromatic compounds has generally required differential prefunctionalization of the arene coupling partners with a halide and an electropositive group. Here we report that palladium, in conjunction with a copper oxidant, can catalyze the cross-coupling of N-acetylindoles and benzenes in high yield and high regioselectivity across a range of indoles without recourse to activating groups. These reactions are completely selective for arene cross-coupling, with no products arising from indole or benzene homo-coupling detected by spectroscopic analysis. This efficient reactivity should be useful in the design of other oxidative arene cross-couplings as well.

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Sigma-Aldrich
Palladium(II)-trifluoracetat, 97%