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  • Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7.

Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7.

Chemical communications (Cambridge, England) (2014-03-13)
Keisuke Fukunaga, Takaaki Hatanaka, Yuji Ito, Michiko Minami, Masumi Taki
ZUSAMMENFASSUNG

By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.

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