- Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.
Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.
Bioorganic & medicinal chemistry letters (2011-07-19)
Richard Ducray, Clifford D Jones, Frederic H Jung, Iain Simpson, Jon Curwen, Martin Pass
PMID21764307
ZUSAMMENFASSUNG
Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition of the hERG ion channel are discussed.
MATERIALIEN