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  • One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate.

One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate.

Organic letters (2012-05-18)
Norio Murai, Masayuki Miyano, Masahiro Yonaga, Keigo Tanaka
ZUSAMMENFASSUNG

A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Methansulfonsäure, ≥99.0%
Sigma-Aldrich
Natriummethansulfonat, 98%
Supelco
Methansulfonsäurekonzentrat, 0.1 M CH3SO3H in water (0.1N), eluent concentrate for IC
Sigma-Aldrich
Kaliummethansulfonat, ≥98.0% (dry substance, T)
Sigma-Aldrich
Methansulfonsäure -Lösung, 70 wt. % in H2O
Sigma-Aldrich
Silbermethansulfonat
Sigma-Aldrich
Methansulfonsäure -Lösung, 4 M (with 0.2% (w/v) tryptamine)