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  • GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.

GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.

Antimicrobial agents and chemotherapy (2009-03-11)
Matthew F McCown, Sonal Rajyaguru, Simran Kular, Nick Cammack, Isabel Nájera
ZUSAMMENFASSUNG

In vitro, telaprevir selects subtype-specific resistance pathways for hepatitis C virus GT-1a and GT-1b, as described to have occurred in patients. In GT-1a, the HCV-796 resistance mutation C316Y has low replication capacity (7%) that can be compensated for by the emergence of the mutation L392F or M414T, resulting in an increase in replication levels of > or = 10-fold.

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Sigma-Aldrich
2-Thiophencarboxylsäure, ReagentPlus®, 99%