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Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.

Nature medicine (2013-02-19)
Lihong Shi, Shuaiying Cui, James D Engel, Osamu Tanabe
ZUSAMMENFASSUNG

Enhanced fetal γ-globin synthesis alleviates symptoms of β-globinopathies such as sickle cell disease and β-thalassemia, but current γ-globin-inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or β-type globin-transgenic mice enhances γ-globin expression. LSD1 is thus a promising therapeutic target for γ-globin induction, and tranylcypromine may serve as a lead compound for the development of a new γ-globin inducer.

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Produktbeschreibung

Sigma-Aldrich
Anti-Dimethyl-Histon-H3-(Lys4-)Antikörper, Klon CMA303, clone CMA303, from mouse