Z2626

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

• Synonym(e): L-694,599, Squalestatin
• Empirische Formel (Hill-System): C₃₅H₄₃O₁₄Na₃
• CAS-Nummer: 144541-82-2
• Molekulargewicht: 756.68
• MDL-Nummer: MFCD03788025
• UNSPSC-Code: 12352106
• NACRES: NA.77

Eigenschaften

• product name: Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
• Biologische Quelle: microbial
• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• Form: lyophilized powder
• Löslichkeit: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Versandbedingung: wet ice
• Lagertemp.: −20°C

Beschreibung

Anwendung

Zaragozic acid A trisodium salt has been used as:

• a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
• a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
• a cholesterol synthesis inhibitor in T cells

Biochem./physiol. Wirkung

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Rechtliche Hinweise

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)