SRP8027

CD24 (mouse): FC (human)

recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)

• Synonym(e): M1/69-J11D heat stable antigen, NaMN adenylyltransferase 1, Nectadrin, X62 Heat stable antigen (HSA)
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: mouse
• Rekombinant: expressed in HEK 293 cells
• Assay: >90% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~50 kDa by SDS-PAGE
• Verpackung: pkg of 50 μg
• Verunreinigungen: <0.06 EU/μg endotoxin, tested
• UniProt-Hinterlegungsnummer: P24807
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... CD24(100133941)

Beschreibung

Allgemeine Beschreibung

CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

Physikalische Form

Lyophilized from PBS.

Rekonstituierung

Reconstitute with 50 μL deionized water.

Sonstige Hinweise

Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable