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SRP6112

G6PD from E. coli

Name: G6PD from <I>E. coli</I>
Brand: SIGMA

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(e):

Glucose-6-phosphate 1-dehydrogenase, Zwf

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About This Item

CAS-Nummer:

9001-40-5

UNSPSC-Code:

12352204

NACRES:

NA.32

Biologische Quelle

Escherichia coli

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

liquid

Mol-Gew.

55.7 kDa (491 aa, 1-491 aa)

Verpackung

pkg of 100 μg

NCBI-Hinterlegungsnummer

P0AC53

UniProt-Hinterlegungsnummer

P0AC53

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

Escherichia coli ... ZWF(7149716)

Allgemeine Beschreibung

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells by maintaining the level of NADPH.

Specific activity is 8-10 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NAD or NADP.

Biochem./physiol. Wirkung

Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphoglucono-delta-lactone and simultaneously produces NADPH. The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. G6PD deficiency causes acute hemolytic anemia.

Physikalische Form

1 mg/mL solution in 50 mM MES pH 6.0, 0.1 mM PMSF, 2 mM EDTA, 0.5 mM DTT and 10% glycerol.

Angaben zur Herstellung

Centrifuge the vial prior to opening.

Sonstige Hinweise

MAVTQTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGQLN PDTRIIGVGR ADWDKAAYTK VVREALETFM KETIDEGLWD TLSARLDFCN LDVNDTAAFS RLGAMLDQKN RITINYFAMP PSTFGAICKG LGEAKLNAKP ARVVMEKPLG TSLATSQEIN DQVGEYFEEC QVYRIDHYLG KETVLNLLAL RFANSLFVNN WDNRTIDHVE ITVAEEVGIE GRWGYFDKAG QMRDMIQNHL LQILCMIAMS PPSDLSADSI RDEKVKVLKS LRRIDRSNVR EKTVRGQYTA GFAQGKKVPG YLEEEGANKS SNTETFVAIR VDIDNWRWAG VPFYLRTGKR LPTKCSEVVV YFKTPELNLF KESWQDLPQN KLTIRLQPDE GVDIQVLNKV PGLDHKHNLQ ITKLDLSYSE TFNQTHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD SITEAWAMDN DAPKPYQAGT WGPVASVAMI TRDGRSWNEF E

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia.

T J Vulliamy et al.

Proceedings of the National Academy of Sciences of the United States of America, 85(14), 5171-5175 (1988-07-01)

Glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) deficiency is a common genetic abnormality affecting an estimated 400 million people worldwide. Clinical and biochemical analyses have identified many variants exhibiting a range of phenotypes, which have been well characterized from the hematological point

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival.

Robert C Stanton

IUBMB life, 64(5), 362-369 (2012-03-21)

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Many scientists think that the roles and regulation of G6PD in physiology and pathophysiology have been well established as the enzyme was first identified 80 years ago. And

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