SML1466

ABH hydrochloride

≥98% (HPLC)

• Synonym(e): 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• Empirische Formel (Hill-System): C₆H₁₄BNO₄ · HCl
• CAS-Nummer: 194656-75-2
• Molekulargewicht: 211.45
• MDL-Nummer: MFCD22887376
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825900
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +8 to +13°, c = 0.7 in H₂O
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• InChIKey: XCUVEZUCSHVMRK-JEDNCBNOSA-N

Beschreibung

Biochem./physiol. Wirkung

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable