Q0875

Chinidin -sulfat (Salz) Dihydrat

• Empirische Formel (Hill-System): C₄₀H₄₈N₄O₄ · H₂O₄S · 2H₂O
• CAS-Nummer: 6591-63-5
• Molekulargewicht: 782.94
• EG-Nummer: 200-046-3
• MDL-Nummer: MFCD00149346
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277870
• NACRES: NA.77

Eigenschaften

• Verunreinigungen: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp (Schmelzpunkt): 212-214 °C (dec.) (lit.)
• Ersteller: Bayer
• SMILES String: [H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
• InChIKey: ZHNFLHYOFXQIOW-WFTMRWCJSA-N

Beschreibung

Allgemeine Beschreibung

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Anwendung

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Biochem./physiol. Wirkung

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

Class IA antiarrhythmic; potassium channel blocker.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves