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I9905

Sigma-Aldrich

Interleukin-2/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution

Synonym(e):

IL-2:Fc (non-lytic)

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About This Item

MDL-Nummer:
MFCD03457247
UNSPSC-Code:
51111800
NACRES:
NA.32

Biologische Quelle

mouse

Qualitätsniveau

200

Rekombinant

expressed in CHO cells

Assay

>98% (SDS-PAGE)

Form

solution

Mol-Gew.

94 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

0.1 mg/mL

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P04351

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

mouse ... Il2(16183)

Biochem./physiol. Wirkung

IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).
Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain.

Sonstige Hinweise

Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc.

Physikalische Form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Hinweis zur Analyse

The biological activity is measured in a cell proliferation assay using CTLL2 cells.

Lagerklassenschlüssel

10 - Combustible liquids

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various
Parul Mehra et al.
Molecular and cellular biology, 35(22), 3880-3891 (2015-09-10)
Interleukin-2 (IL-2) is a potent cytokine with roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role for Il2 in autoimmune disease susceptibility, and for decades the proximal Il2 upstream regulatory region has served as

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