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G3295

Sigma-Aldrich

GW0742

≥98% (HPLC)

Synonym(e):

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

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About This Item

Empirische Formel (Hill-System):
C21H17F4NO3S2
CAS-Nummer:
317318-84-6
Molekulargewicht:
471.49
MDL-Nummer:
MFCD07369423
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24895123
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white

mp (Schmelzpunkt)

134.5-135.5 °C

Löslichkeit

DMSO: >5 mg/mL
H2O: insoluble

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

InChIKey

HWVNEWGKWRGSRK-UHFFFAOYSA-N

Angaben zum Gen

human ... PPARA(5465) , PPARD(5467) , PPARG(5468)

Biochem./physiol. Wirkung

GW0742 is a highly selective PPARδ agonist. EC50 = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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PPARβ/δ activation protects against endothelial dysfunction in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on
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The Journal of biological chemistry, 292(3), 884-897 (2016-12-04)
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