D5891

1,1-Dimethyl-4-phenylpiperaziniumjodid

≥98% (TLC or titration)

• Synonym(e): DMPP
• Empirische Formel (Hill-System): C₁₂H₁₉IN₂
• CAS-Nummer: 54-77-3
• Molekulargewicht: 318.20
• Beilstein: 3746109
• EG-Nummer: 200-213-0
• MDL-Nummer: MFCD00011976
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277832
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC or titration)
• Form: powder
• mp (Schmelzpunkt): 234-238 °C (lit.)
• Löslichkeit: H₂O: 21 mg/mL
• Lagertemp.: −20°C
• SMILES String: [I-].C[N+]1(C)CCN(CC1)c2ccccc2
• InChI: 1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
• InChIKey: XFZJGFIKQCCLGK-UHFFFAOYSA-M
• Angaben zum Gen: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) ; rat ... Chrna2(170945) , Chrna3(25101) , Chrna4(25590) , Chrnb2(54239) , Chrnb4(25103)

Beschreibung

Anwendung

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

• to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
• to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
• to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

Biochem./physiol. Wirkung

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves