C9012

Bis(cyclohexanon)oxaldihydrazon

≥95% purity (TLC), powder

• Synonym(e): Cuprizon, Oxalsäure-bis-(cyclohexylidenhydrazid)
• Empirische Formel (Hill-System): C₁₄H₂₂N₄O₂
• CAS-Nummer: 370-81-0
• Molekulargewicht: 278.35
• Beilstein: 2388004
• EG-Nummer: 206-729-2
• MDL-Nummer: MFCD00001659
• UNSPSC-Code: 12171500
• PubChem Substanz-ID: 24893128
• NACRES: NA.47

Eigenschaften

• product name: Bis(cyclohexanon)oxaldihydrazon, ≥95% (TLC)
• Assay: ≥95% (TLC)
• Form: powder
• Farbe: white/clear to off-white
• mp (Schmelzpunkt): 210-214 °C (lit.)
• Löslichkeit: acetic acid: 50 mg/mL, colorless to very faintly brown
• Anwendung(en): diagnostic assay manufacturing; hematology; histology
• Lagertemp.: 2-8°C
• SMILES String: O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
• InChI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
• InChIKey: DSRJIHMZAQEUJV-UHFFFAOYSA-N

Beschreibung

Anwendung

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Biochem./physiol. Wirkung

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)