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P1200000

Phenylbutazon

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

4-Butyl-1,2-diphenyl-3,5-pyrazolidindion

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About This Item

Empirische Formel (Hill-System):
C19H20N2O2
CAS-Nummer:
50-33-9
Molekulargewicht:
308.37
MDL-Nummer:
MFCD00005500
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329820078
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

phenylbutazone

Hersteller/Markenname

EDQM

mp (Schmelzpunkt)

106-108 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

InChI

1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3

InChIKey

VYMDGNCVAMGZFE-UHFFFAOYSA-N

Angaben zum Gen

human ... PTGS1(5742) , PTGS2(5743)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Phenylbutazone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Preisangaben

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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J Aarbakke
Clinical pharmacokinetics, 3(5), 369-380 (1978-09-01)
More than 25 years after phenylbutazone was introduced as a non-steroidal anti-inflammatory agent, basic knowledge is still accumulating on its pharmacokinetics in man. Phenylbutazone is almost completely absorbed after oral administration. A large fraction of the drug in plasma is
Robert D Combes
Alternatives to laboratory animals : ATLA, 41(3), 235-248 (2013-08-27)
Published in silico, in vitro, in vivo laboratory animal and human data, together with information on biotransformation and data from structure-activity analyses with two decision-tree systems (ACToR and Toxtree), have been used in a weight-of-evidence (WoE) assessment to determine whether
T Tobin et al.
Journal of veterinary pharmacology and therapeutics, 9(1), 1-25 (1986-03-01)
Phenylbutazone is an acidic, lipophilic, non-steroidal anti-inflammatory drug (NSAID). It is extensively metabolized in the horse. The metabolites so far identified, oxyphenbutazone, gamma-hydroxyoxyphenbutazone, account for some 25-30% of administered dose over 24 h. The plasma half-life of phenylbutazone and termination
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
F Tolot et al.
Semaine des hopitaux. Therapeutique, 52(3), 185-190 (1976-03-01)
M Maciazek-Jurczyk et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 1-9 (2009-07-21)
The monitoring of drug concentration in blood serum is necessary in multi-drug therapy. Mechanism of drug binding with serum albumin (SA) is one of the most important factors which determine drug concentration and its transport to the destination tissues. In
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