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Dokumente

D8809

Sigma-Aldrich

Daunorubicin -hydrochlorid

meets USP testing specifications

Synonym(e):

Daunomycin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C27H29NO10 · HCl
CAS-Nummer:
23541-50-6
Molekulargewicht:
563.98
Beilstein:
4229221
EG-Nummer:
245-723-4
MDL-Nummer:
MFCD04974507
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24894229
NACRES:
NA.21

Agentur

USP/NF
meets USP testing specifications

Qualitätsniveau

200

Form

solid

Wirkungsspektrum von Antibiotika

neoplastics

Wirkungsweise

DNA synthesis | interferes

Lagertemp.

2-8°C

SMILES String

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChIKey

GUGHGUXZJWAIAS-QQYBVWGSSA-N

Angaben zum Gen

human ... TOP2A(7153)

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Biochem./physiol. Wirkung

Wirksames Antikrebsmittel. Hemmt die DNA- und RNA-Synthese als sequenzspezifisches ds-DNA interkalierendes Mittel. Eigenschaften
Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Analysenzertifikate (COA)

Lot/Batch Number
WXBD6119V
WXBD4542V
SLCC6692
SLBX6832
WXBC5749V

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Sigma-Aldrich

44583

Doxorubicin -hydrochlorid

Doxorubicin-Hydrochlorid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1789

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Sigma-Aldrich

251010

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USP

USP

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USP

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USP

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Devika Prasanth et al.
Life (Basel, Switzerland), 10(9) (2020-08-28)
Microgravity or the condition of apparent weightlessness causes bone, muscular and immune system dysfunctions in astronauts following spaceflights. These organ and system-level dysfunctions correlate with changes induced at the single cell level both by simulated microgravity on earth as well
E J Wang et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(5), 522-528 (2000-04-20)
P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many drugs. A simple and reliable in vitro method to identify inhibitors of Pgp helps to prevent the potential of drug interactions. Using
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The Journal of biological chemistry, 278(50), 50234-50239 (2003-10-03)
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Multidrug resistance is a major cause of chemotherapy failure. Recent studies indicate that drug resistance can be rapidly induced by some soluble factors, such as cytokines, chemokines, growth factors, and cell adhesion factors in the tumor microenvironment. Osteopontin (OPN), an
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The mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients. We conducted a phase Ib trial combining RAD001 (everolimus), an allosteric inhibitor of mTORC1, and conventional chemotherapy, in AML patients under 65 years of age
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