MABF248

Anti-SLFN11 Antibody, clone 4G9

clone 4G9, 0.25 mg/mL, from mouse

• Synonym(e): Schlafen family member 11, SLFN11
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 4G9, monoclonal
• Speziesreaktivität: human
• Konzentration: 0.25 mg/mL
• Methode(n): immunoprecipitation (IP): suitable; western blot: suitable
• Isotyp: IgMκ
• NCBI-Hinterlegungsnummer: NP_001098057
• UniProt-Hinterlegungsnummer: Q7Z7L1
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SLFN11(91607)

Beschreibung

Allgemeine Beschreibung

SLFN11, also known as Schlafen family member 11, and encoded by the gene SLFN11, is an interesting protein that is part of our innate defense against retroviruses. The protein is induced by interferon and acts to inhibit the translation of retrovirus specific proteins. SLFN11 also plays a role in cell cycle arrest and apoptosis induction, particularly in response to DNA damage. SLFN11 is localized to the nucleus and is widely expressed and up regulated in various cancers including ovarian and adenocarcinomas, and recent work suggests that SLFN11 may behave as a biomarker for prediction of response to DNA-damaging agents in the clinical setting.

Immunogen

Recombinant protein corresponding to human SLFN11.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

Anti-SLFN11 Antibody, clone 4G9 is an antibody against SLFN11 for use in western blotting & IP.

Western Blotting/Immunoprecipitation Analysis: A representative lot immunoprecipitated SLFN11 from transfected HEK293 cell lysates. The same lot was used to detect SLFN11 in Western Blotting (Prof. Michael David, University of California, San Diego.).

Electron Mobility Shift Assay Analysis: A representative lot from an independent laboratory detected SLFN11 bound t-RNA (Li, M., et al. (2012). Nature. 491(7422):125-128.).

Qualität

Evaluated by Western Blotting in HEK293T cell lysates transfected with SLFN11 or a negative control.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SFN11 in HEK293T cell lysates transfected with SLFN11 and not in HEK293T cell lysates transfected with a negative control.

Zielbeschreibung

~100 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Physikalische Form

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable