930644

VH 032 amide-PEG₂-acid

≥95%

• Synonym(e): (S,R.S)-AHPC-PEG₂-acid, (S,R,S)-AHPC-CO-PEG₂-C₂-acid, 3-[2-(2-{[(2S)-1-[(2S,4R)-4-Hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]propanoic acid, L-Prolinamide, N-[3-[2-(2-carboxyethoxy)ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Empirische Formel (Hill-System): C₃₀H₄₂N₄O₈S
• CAS-Nummer: 2172820-09-4
• Molekulargewicht: 618.74
• MDL-Nummer: MFCD32670313
• UNSPSC-Code: 12352106

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Funktionelle Gruppe: carboxylic acid
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

VH 032 amide-PEG₂-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

Sonstige Hinweise

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable