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MMP14

matrix metallopeptidase 14 (membrane-inserted)

Synonyme:
MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(4323) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
  • Mouse(17387) matrix metallopeptidase 14 (membrane-inserted)
  • Rat(81707) matrix metallopeptidase 14 (membrane-inserted)
  • chicken(426253) matrix metallopeptidase 14 (membrane-inserted)
  • cow(281915) matrix metallopeptidase 14 (membrane-inserted)
  • Horse(100034170) matrix metallopeptidase 14 (membrane-inserted)
  • domestic cat(101089776) matrix metallopeptidase 14 (membrane-inserted)
  • dog(403823) matrix metallopeptidase 14 (membrane-inserted)
  • naked mole-rat(101723795) matrix metallopeptidase 14 (membrane-inserted)
  • Domestic Rabbit(100009598) matrix metallopeptidase 14 (membrane-inserted)
  • domestic guinea pig(100732039) matrix metallopeptidase 14 (membrane-inserted)
  • sheep(443116) matrix metallopeptidase 14 (membrane-inserted)

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8, clone LEM-2/15.8, Chemicon®, from mouse,
Speziesreaktivität
human, mouse
Anwendung
ELISA
immunoprecipitation (IP)

western blot
Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/63.1, clone LEM-2/63.1, Chemicon®, from mouse,
Speziesreaktivität
mouse
Anwendung
ELISA
immunoprecipitation (IP)

western blot
Anti-MMP-14 Antibody, serum, Chemicon®,
Speziesreaktivität
human
Anwendung
ELISA
flow cytometry

immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-MMP-14 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-MMP14 (Cleaved-Tyr112) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Marimastat, ≥98% (HPLC),
Spezies
human, rat, mouse
CP-101537, ≥98% (HPLC),
Spezies
human, rat, mouse
CP-471474, ≥98% (HPLC),
Spezies
human, rat, mouse
PD166793 hydrate, ≥98% (HPLC),
Spezies
human, rat, mouse

Proteins

Produktnummer
Beschreibung
Spezies
MMP-14, human, prodomain, catalytic domain, and hemopexin domain, E. coli recombinant, ,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human MMP14,
Spezies
human
MISSION® esiRNA, targeting mouse Mmp14,
Spezies
mouse