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Merck

LMNA

lamin A/C

Synonyme:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • Zebrafish(195815) lamin A
  • cow(404144) lamin A/C
  • Horse(100057663) lamin A/C
  • domestic cat(101086199) lamin A/C
  • dog(480124) lamin A/C
  • chicken(415464) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • naked mole-rat(101704567) lamin A/C
  • sheep(101107924) lamin A/C

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Progerin-Antikörper, Klon 13A4, clone 13A4, Upstate®, from mouse,
Speziesreaktivität
human
Anwendung
ELISA
immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-prelamin A Antibody, clone PL-1C7, clone PL-1C7, from mouse,
Speziesreaktivität
human, mouse
Anwendung
ELISA
flow cytometry

immunocytochemistry

western blot
Anti-Progerin antibody, Mouse monoclonal, clone 13A4, purified from hybridoma cell culture,
Speziesreaktivität
human
Anwendung
immunofluorescence
immunoprecipitation (IP)

western blot
Anti-Prälamin-A-Antikörper, Klon 7G11, clone 7G11, from rat,
Speziesreaktivität
mouse
Anwendung
immunofluorescence
western blot
Anti-Lamin A Antibody, CT, a.a. 598-611, clone 133A2, clone 133A2, Chemicon®, from mouse,
Speziesreaktivität
bovine, canine, human, mouse, rat
Anwendung
flow cytometry
immunocytochemistry

immunohistochemistry

western blot

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting mouse Lmna,
Spezies
mouse
MISSION® esiRNA, targeting human LMNA,
Spezies
human