Direkt zum Inhalt
Merck

ESR2

estrogen receptor 2 (ER beta)

Synonyme:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Activator

Produktnummer
Beschreibung
Spezies
β-Nicotinamidadenin-Dinucleotid Natriumsalz, ,
Spezies
human
β-Nicotinamidadenin-Dinucleotid Hydrat, ≥95% (HPLC),
Spezies
human
β-Nicotinamidadenin-Dinucleotid, pkg of 10 mg (per vial),
Spezies
human
β-Nicotinamidadenin-Dinucleotid, pkg of 50 mg (per vial),
Spezies
human
β-Nicotinamidadenin-Dinucleotid Hydrat, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Spezies
human

Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
ERB-041, ≥98% (HPLC),
Spezies
human
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Spezies
human
Estron, ≥99%,
Spezies
human, mouse, rat

Small Molecule - Allosteric Modulator

Produktnummer
Beschreibung
Spezies
Raloxifen -hydrochlorid, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Raloxifen -hydrochlorid, solid,
Spezies
human
Estramustine sodium phosphate, ,
Spezies
human
Raloxifen-Hydrochlorid, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human
Raloxifen -hydrochlorid, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Fulvestrant, >98% (HPLC),
Spezies
human
2-Methoxyestradiol, powder,
Spezies
human
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Spezies
human
Fulvestrant für die Systemeignung, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal, clone 68-4, Upstate®, from rabbit,
Speziesreaktivität
human
Anwendung
immunoprecipitation (IP)
western blot
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Speziesreaktivität
human, monkey, mouse
Anwendung
ChIP
dot blot

flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunofluorescence

western blot
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Speziesreaktivität
human, mouse, rat
Anwendung
immunoprecipitation (IP)
western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
western blot

Cell Lines

Produktnummer
Beschreibung
Spezies
MCF10A CELLS ESR2 (-/-), ,
Spezies
human

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
α-Oestradiol, powder, ≥98% (TLC),
Spezies
human, rat
β-Estradiol, meets USP testing specifications,
Spezies
human, mouse, rat
β-Estradiol, BioReagent, powder, suitable for cell culture,
Spezies
human, mouse, rat
β-Estradiol, ≥98%,
Spezies
human, mouse, rat
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Spezies
human, mouse, rat

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human ESR2,
Spezies
human