Direkt zum Inhalt
Merck

DNASE1

deoxyribonuclease I

Synonyme:
DNL1, DRNI
Spezies:
Human DNASE1 (1773), Mouse Dnase1 (13419), Rat Dnase1 (25633), Zebrafish dnase1 (436947), dog DNASE1 (403413), domestic cat DNASE1 (101096195), cow DNASE1 (282217), Horse DNASE1 (100034219), chicken DNASE1 (395725), sheep DNASE1 (101122154) ...Mehr
UniProtKB-ID:
P24855, Q14UU9, Q14UV0
Gen-ID:
  • Human(1773) Summary: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13419) deoxyribonuclease I
  • Rat(25633) deoxyribonuclease I
  • Zebrafish(436947) deoxyribonuclease I
  • dog(403413) deoxyribonuclease I
  • domestic cat(101096195) deoxyribonuclease I
  • cow(282217) deoxyribonuclease I
  • Horse(100034219) deoxyribonuclease I
  • chicken(395725) deoxyribonuclease I
  • sheep(101122154) deoxyribonuclease I
  • Domestic Rabbit(100009513) deoxyribonuclease I
  • naked mole-rat(101713435) deoxyribonuclease I
  • domestic guinea pig(100718441) deoxyribonuclease I

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
HPA010703
Anti-DNASE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
SAB2108830
Anti-DNASE1 (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
bovine, human, rat
Anwendung
western blot
SAB2108831
Anti-DNASE1 (N-terminal) antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Speziesreaktivität
bovine, human, rat
Anwendung
SAB2108832
Anti-DNASE1 (N-terminal) antibody produced in rabbit HRP conjugated, affinity isolated antibody,
Speziesreaktivität
bovine, human, rat
Anwendung

Proteins

Produktnummer
Beschreibung
Spezies
DN25
Deoxyribonuclease I aus Rinderpankreas, lyophilized powder, Protein ≥85 %, ≥400 Kunitz units/mg protein,
Spezies
D5025
Deoxyribonuclease I aus Rinderpankreas, Type IV, lyophilized powder, ≥2,000 Kunitz units/mg protein,
Spezies
D4527
Deoxyribonuclease I aus Rinderpankreas, Type II, lyophilized powder, Protein ≥80 %, ≥2,000 units/mg protein,
Spezies
D4513
Deoxyribonuclease I aus Rinderpankreas, Type II-S, lyophilized powder, Protein ≥80 %, ≥2,000 units/mg protein,
Spezies
04536282001
DNase I, rekombinant, grade I, from bovine pancreas, expressed in Pichia pastoris,
Spezies
cow