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Merck

CHRM4

cholinergic receptor, muscarinic 4

Synonyme:
HM4, M4R
Spezies:
Human CHRM4 (1132), Mouse Chrm4 (12672), Rat Chrm4 (25111), chicken CHRM4 (423195), cow CHRM4 (512928), domestic cat CHRM4 (101088360), dog CHRM4 (611314), sheep CHRM4 (101114554), Domestic Rabbit CHRM4 (100008791), domestic guinea pig Chrm4 (100714736)
UniProtKB-ID:
P08173, B2RPP4, Q0VD60, Q4VBK7
Gen-ID:
  • Human(1132) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
  • Mouse(12672) cholinergic receptor, muscarinic 4
  • Rat(25111) cholinergic receptor, muscarinic 4
  • chicken(423195) cholinergic receptor, muscarinic 4
  • cow(512928) cholinergic receptor, muscarinic 4
  • domestic cat(101088360) cholinergic receptor, muscarinic 4
  • dog(611314) cholinergic receptor, muscarinic 4
  • sheep(101114554) cholinergic receptor, muscarinic 4
  • Domestic Rabbit(100008791) cholinergic receptor, muscarinic 4
  • domestic guinea pig(100714736) cholinergic receptor, muscarinic 4
  • naked mole-rat(101726411) cholinergic receptor, muscarinic 4

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
P6503
Pilocarpin -hydrochlorid, ≥99% (titration), powder,
Spezies
human
A2251
Acetyl-β-Methylcholin-Chlorid, ≥98% (TLC), powder,
Spezies
human
P6628
Pilocarpin -nitrat (Salz), ≥98% (HPLC),
Spezies
human
O100
Oxotremorine M, solid,
Spezies
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
B1390
Bisacodyl, analytical standard, for drug analysis,
Spezies
human
T9778
Tropicamid, solid,
Spezies
human
S1875
(−)-Scopolamin -hydrobromid Trihydrat, ≥98% (HPLC), powder,
Spezies
human
A0257
Atropin -sulfat (Salz) Monohydrat, ≥97% (TLC), crystalline,
Spezies
human
S7882
(−)-Scopolamin-N-Butylbromid, ≥98% (TLC), powder,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
MAB1578
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2, clone 18C7.2, Chemicon®, from mouse,
Speziesreaktivität
monkey
Anwendung
immunohistochemistry
immunoprecipitation (IP)
western blot
ZMS1165
Anti-CHRM4 Antibody, clone 18C7.2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human
Anwendung
ELISA
affinity binding assay
immunocytochemistry
western blot
SAB4300824
Anti-CHRM4 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
MAB1576
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2, purified antibody, clone 17F10.2, Chemicon®,
Speziesreaktivität
monkey, mouse, rat
Anwendung
immunocytochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
A8404
Amitriptylin -hydrochlorid, ≥98% (TLC), powder,
Spezies
human
D4526
Doxepin -hydrochlorid, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Spezies
human
51330
Harmalin, ≥95%,
Spezies
human, rat

Small Molecule - Ligand

Produktnummer
Beschreibung
Spezies
A138
Aminobenztropine, solid,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EMU046221
MISSION® esiRNA, targeting mouse Chrm4,
Spezies
mouse