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CASP5

caspase 5, apoptosis-related cysteine peptidase

Synonyme:
ICE(rel)III, ICEREL-III, ICH-3
Spezies:
Human CASP5 (838)
UniProtKB-ID:
P51878, B4DKP5, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6
Gen-ID:
  • Human(838) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
HPA040937
Anti-CASP5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
ABS445
Anti-Caspase-5 Antibody, from rabbit, purified by affinity chromatography,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunofluorescence
western blot
PRS3455
Anti-Caspase-5 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot
SAB4503304
Anti-CASP5 (p10, Cleaved-Ser331) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
ELISA
western blot

Proteins

Produktnummer
Beschreibung
Spezies
C6482
Caspase 5 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EHU127011
MISSION® esiRNA, targeting human CASP5,
Spezies
human