This webinar, hosted by Separation Science, emphasizes the significance of capillary HPLC coupled with mass spectrometry in two parts. The first part discusses our Lipidomics Analytical Platform for mRNA Lipid Nanoparticle (LNP) Innovation, aiming to study LNP metabolization and predict metabolites for regulatory approval of LNP-based therapeutics. The second part focuses on the use of liquid chromatography-mass spectrometry (LC-MS) as a powerful tool for studying organoids and organ-on-chip (OoC) models. These models, used as alternatives to animal models, require sensitive analytical tools, and LC-MS methods for proteomics, lipidomics, peptidomics, and drug metabolism studies are being developed and applied for this purpose. The presentation also highlights the advantages of miniaturization of the LC system and on-line analysis for sensitive and automated measurements with minimal sample loss and contamination.
By watching the presentation, you will learn:
- How to develop sensitive and selective LC-MS analysis of organoids
- How to tailor sample preparation procedures to fit the uniqueness of such biosamples
- How to proceed with method validation
Speakers
Dr. Jasjot Singh
Merck
Senior Scientist, Biomolecule Analytics Lab, Central Analytics
Jasjot is a biochemist holding a PhD in LC-MS-based proteomics from the University of Bonn (2022), specializing in molecular biology. He transitioned directly to Merck KGaA, Darmstadt, Germany, where he now serves as a senior scientist in the biomolecule analytics lab of Central Analytics. In his current role, Jasjot leads diverse proteomics projects, including biomarker discovery and targeted protein degradation. He focuses on developing customized LC-MS workflows for protein, lipid, and metabolite analytics. His primary goals involve standardizing and automating workflows to enable high-throughput "omics" analysis, as well as optimizing streamlined data analysis pipelines.
Prof. Steven Ray Wilson
University of Oslo, Norway
Department of Chemistry
Steven Ray Wilson is a professor at the Department of Chemistry, University of Oslo. He is a principal investigator in a center of excellence that focuses on the development and study of organoids/OoCs in the Hybrid Technology Hub. He has close ties to the analytical community, as well as long-term collaborations with medical partners for clinical applications, for example.
Analytical chemistry
- Low pressure liquid chromatography
Dauer:1h
Sprache:English
Sitzung 1:vorgestellt October 17, 2024
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