- The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid.
The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid.
Scientific reports (2017-02-07)
Shun-Tao Luo, Dong-Mei Zhang, Qing Qin, Lian Lu, Min Luo, Fu-Chun Guo, Hua-Shan Shi, Li Jiang, Bin Shao, Meng Li, Han-Shuo Yang, Yu-Quan Wei
PMID28165036
ABSTRACT
The simultaneous increases in blood lactic acid and erythrocytes after intense exercise could suggest a link between lactate and the erythropoiesis. However, the effects of lactic acid on erythropoiesis remain to be elucidated. Here, we utilized a mouse model to determine the role of lactic acid in this process in parallel with studies using leukaemic K562 cells. Treatment of K562 cells in vitro with lactic acid increased the mRNA and protein expression of haemoglobin genes and the frequency of GPA
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Human EPO / Erythropoietin ELISA Kit, for serum, plasma, cell culture supernatants and urine