- Pharmacokinetic profile of indoprofen in elderly subjects.
Pharmacokinetic profile of indoprofen in elderly subjects.
British journal of clinical pharmacology (1986-12-01)
B Lund, C Egsmose, O Knudsen, R B Andersen
PMID3567017
ABSTRACT
Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.