- KI-catalyzed imidation of sp3 C-H bond adjacent to amide nitrogen atom.
KI-catalyzed imidation of sp3 C-H bond adjacent to amide nitrogen atom.
Organic & biomolecular chemistry (2012-09-06)
Zhi-Qi Lao, Wen-He Zhong, Qing-Hua Lou, Zhong-Jun Li, Xiang-Bao Meng
PMID22948963
ABSTRACT
We have developed a new KI-catalyzed method for the imidation of an sp(3) C-H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to excellent yields under mild conditions.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Potassium iodide, puriss., meets analytical specification of Ph. Eur. BP, USP, 99.0-100.5% (calc. to the dried substance)