- Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Bioorganic & medicinal chemistry letters (2012-05-15)
Gary E Keck, Yam B Poudel, Arnab Rudra, Jeffrey C Stephens, Noemi Kedei, Nancy E Lewin, Peter M Blumberg
PMID22579485
ABSTRACT
The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin.
MATERIALS