- A simple and convenient copper-catalyzed tandem synthesis of quinoline-2-carboxylates at room temperature.
A simple and convenient copper-catalyzed tandem synthesis of quinoline-2-carboxylates at room temperature.
The Journal of organic chemistry (2009-07-04)
He Huang, Hualiang Jiang, Kaixian Chen, Hong Liu
PMID19572501
ABSTRACT
We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.
MATERIALS