Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.

Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.

Antimicrobial agents and chemotherapy (2008-07-16)

Jan Paeshuyse, Inge Vliegen, Lotte Coelmont, Pieter Leyssen, Oriana Tabarrini, Piet Herdewijn, Harald Mittendorfer, Johnny Easmon, Violetta Cecchetti, Ralf Bartenschlager, Gerhard Puerstinger, Johan Neyts

PMID18625766

ABSTRACT

We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.

MATERIALS

Product Number

Brand

Product Description

T32603

Sigma-Aldrich

2-Thiophenecarboxylic acid, ReagentPlus^®, 99%

C3662

Sigma-Aldrich

Cyclosporin A, from Tolypocladium inflatum, ≥95% (HPLC), solid

30024

Sigma-Aldrich

Cyclosporin A, 97.0-101.5% (on dried basis)

32425

Supelco

Cyclosporin A, VETRANAL^®, analytical standard

C1832

Sigma-Aldrich

Cyclosporin A, BioReagent, from Tolypocladium inflatum, for molecular biology, ≥95%