567310-M

SKF-96365, Hydrochloride

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release.

• Synonym(s): SKF-96365, Hydrochloride, 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
• Empirical Formula (Hill Notation): C₂₂H₂₆N₂O₃ · xHCl
• CAS Number: 130495-35-1
• Molecular Weight: 366.45 (free base basis)
• MDL number: MFCD00236407
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 2 mg/mL
• storage temp.: 10-30°C
• InChI: 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
• InChI key: FWLPKVQUECFKSW-UHFFFAOYSA-N

Description

General description

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Biochem/physiol Actions

Primary Target
Inhibits receptor-mediated Ca2+ entry

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605.
Schwartz, G., et al. 1994. Cell Calcium15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J.271, 515.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable