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Merck
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Documents

19-142

Sigma-Aldrich

LY 294002

Synonym(s):

NSC 697286, PI3K inhibitor, SF 1101

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

form

solid

Quality Level

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

shipped in

wet ice

Application

Specific and potent inhibitor of PI 3-kinase.

Biochem/physiol Actions

Inhibitor Type: Kinase

Physical form

C19H17NO3

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

487.4 °F

Flash Point(C)

253.0 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wen Jiang et al.
Bioengineered, 12(2), 10264-10284 (2021-11-02)
Chronic skin ulcers are a primary global health problem. Velvet antler polypeptide (VAP) regulates endothelial cell migration and angiogenic sprout. Adipose-derived stem cells (ADSCs) are reported to make pivotal impacts upon wound healing. This study aimed to explore the role
C J Vlahos et al.
The Journal of biological chemistry, 269(7), 5241-5248 (1994-02-18)
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and nonreceptor tyrosine kinases, including the platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a better understanding of the function and
Hongxiu Han et al.
The American journal of pathology, 191(3), 515-526 (2020-12-22)
Nerve infiltration into the tumor is a common feature of the tumor microenvironment. The mechanisms of axonogenesis in breast cancer remain unclear. We hypothesized that vascular endothelial growth factor (VEGF), as well as nerve growth factor (NGF), is involved in
Satoru Takahashi et al.
The Journal of biological chemistry, 278(33), 30821-30827 (2003-06-12)
Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. We recently used purified proteins to characterize the mechanisms by which heat shock protein 90 (HSP90) increases eNOS activity
Banglao Xu et al.
Gut microbes, 13(1), 1968258-1968258 (2021-08-26)
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory activities in Clostridioides difficile infection. Here, we have shown that cytokine IL-27

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