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Merck
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Key Documents

Altri documenti

SML0264

Sigma-Aldrich

AEG 3482

≥98% (HPLC)

Sinonimo/i:

6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

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About This Item

Formula empirica (notazione di Hill):
C10H8N4O2S2
Numero CAS:
63735-71-7
Peso molecolare:
280.33
Numero MDL:
MFCD02064987
Codice UNSPSC:
12352200
ID PubChem:
329825272
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

faintly yellow to dark yellow

Solubilità

DMSO: ≥15 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3

InChI

1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
MQUYTXDAVCOCMX-UHFFFAOYSA-N

Azioni biochim/fisiol

AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.

Caratteristiche e vantaggi

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Amir H Salehi et al.
Chemistry & biology, 13(2), 213-223 (2006-02-24)
We describe a group of small-molecule inhibitors of Jun kinase (JNK)-dependent apoptosis. AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons after NGF withdrawal. We show that AEG3482
Karthiga Santhana Kumar et al.
SpringerPlus, 4, 19-19 (2015-01-28)
Medulloblastoma (MB) comprises four molecularly and genetically distinct subgroups of embryonal brain tumors that develop in the cerebellum. MB mostly affects infants and children and is difficult to treat because of frequent dissemination of tumor cells within the leptomeningeal space.
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where

Articoli

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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