SML0198

Fenoldopam mesylate

≥98% (HPLC)

• Sinonimo/i: Fenoldopam methanesulfonate
• Formula empirica (notazione di Hill): C₁₆H₁₆ClNO₃ · CH₄O₃S
• Numero CAS: 67227-57-0
• Peso molecolare: 401.86
• Numero CE: 266-612-7
• Numero MDL: MFCD04112986
• Codice UNSPSC: 12352200
• ID PubChem: 329825223
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to tan
• Punto di fusione: 271 °C (lit.)
• Solubilità: DMSO: ≥15 mg/mL at ~60 °C
• Temperatura di conservazione: room temp
• Stringa SMILE: CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
• InChI: 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4); CVKUMNRCIJMVAR-UHFFFAOYSA-N
• Informazioni sul gene: human ... DRD1(1812)

Descrizione

Applicazioni

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

Azioni biochim/fisiol

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.

Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

Caratteristiche e vantaggi

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317,H319
• Consigli di prudenza: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable