SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 47 kDa; antigen 76 kDa
• Reattività contro le specie: human
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:20000; western blot: 1:500-1:1000
• N° accesso NCBI: P09871
• N° accesso UniProt: P09871
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: proteolytically cleaved (Arg437)
• Informazioni sul gene: human ... C1S(716)

Descrizione

Descrizione generale

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷ Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg⁴³⁷protein.

The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

Immunogeno

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

Azioni biochim/fisiol

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable