SAB3500514

Anti-ZEB1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-AREB6, Anti-BZP, Anti-TCF8, Anti-Zinc finger E-box binding homeobox 1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: predicted mol wt 124 kDa
• Reattività contro le specie: human
• tecniche: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso NCBI: CAI12550
• N° accesso UniProt: P37275
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ZEB1(6935)

Descrizione

Descrizione generale

Zinc finger E-box-binding homeobox 1 (ZEB1) is an EMT (epithelial-mesenchymal transition) transcription factor. The gene encoding this protein is localized on human chromosome 10p11.2.

Immunogeno

ZEB1 antibody was raised against a 15 amino acid peptide near the center of human ZEB1.

The immunogen is located within amino acids 530 - 580 of ZEB1.

Applicazioni

Anti-ZEB1 antibody produced in rabbit has been used in western blotting.

Azioni biochim/fisiol

Zinc finger E-box-binding homeobox 1 (ZEB1) controls the expression of E-cadherin as a repressor. It plays an important role in tumor invasion and metastasis. Epigenetic suppression of ZEB1 might be a useful tool for overcoming drug resistance in human breast cancer. Mutations in this gene are associated with posterior polymorphous corneal dystrophy and Fuchs′ endothelial corneal dystrophy (FECD6).

Caratteristiche e vantaggi

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500514.

Stato fisico

Supplied in PBS with 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable