SAB2501392

Anti-EPS8 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Epidermal growth factor receptor pathway substrate 8
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: goat
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: mouse, canine, human, rat
• tecniche: immunohistochemistry: suitable; indirect ELISA: suitable
• N° accesso UniProt: Q12929
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... EPS8(2059)

Descrizione

Descrizione generale

The gene EPS8 (epidermal growth factor receptor pathway substrate 8) is mapped to human chromosome 12p12. The protein has a phosphotyrosine-binding (PTB) domain at the N-terminal, an SH3 (src homology 3) domain and an effector domain at the C-terminal.

Immunogeno

Peptide with sequence SGVESFDEGSSH, from the C-terminal region of the protein sequence according to NP_004438.3

Azioni biochim/fisiol

EPS8 (epidermal growth factor receptor pathway substrate 8) is a substrate for tyrosine kinases, such as epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and ERBB2 (erb-b2 receptor tyrosine kinase 2). In addition, it also interacts with the Src non-receptor tyrosine kinase. The protein is involved in Rac signaling and receptor endocytosis. It also regulates dendritic cell migration, morphogenesis of intestinal cells and microvilli, and stereocilia activity. It is upregulated in pancreatic cancer and oral squamous cell carcinoma. Mutation in EPS8 is associated with autosomal recessive profound deafness.

Caratteristiche e vantaggi

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Stato fisico

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable