PZ0005

Voriconazole

≥98% (HPLC), powder, ergosterol synthesis inhibitor

• Sinonimo/i: 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496
• Formula empirica (notazione di Hill): C₁₆H₁₄F₃N₅O
• Numero CAS: 137234-62-9
• Peso molecolare: 349.31
• Numero MDL: MFCD00905717
• Codice UNSPSC: 12352200
• ID PubChem: 329823674
• NACRES: NA.77

Proprietà

• product name: Voriconazole, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1; BCEHBSKCWLPMDN-MGPLVRAMSA-N

Descrizione

Descrizione generale

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Applicazioni

Voriconazole has been used:

• as a control and Erg11 inhibitor in YPD medium
• as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
• as an antifungal agent to test its interactions with valproic acid (VPA)
• to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Azioni biochim/fisiol

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H341,H351,H361,H371,H372,H373,H412
• Consigli di prudenza: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
• Organi bersaglio: Eyes, Liver,Kidney
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable