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N1408

Sigma-Aldrich

NGF-β human

from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sinonimo/i:

HSAN5, NGFB, hNGFβ

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About This Item

Numero MDL:
MFCD00164982
Codice UNSPSC:
12352202
NACRES:
NA.77

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in NSO cells

Saggio

>97% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

0.15-3.0 ng/mL ED50/EC50

Qualità

endotoxin tested

Confezionamento

pkg of 5X0.1 mg
pkg of 0.1 mg

tecniche

cell culture | mammalian: suitable

Impurezze

<1 EU/μg

Solubilità

water: soluble 0.1 g/L at 20 °C

N° accesso UniProt

P01138

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... NGF(4803)

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Descrizione generale

The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.

Applicazioni

NGF-β human has been used:
  • in protein pin arrays
  • to induce U87-MG (glioblastoma cell line) cell proliferation
  • in drug release kinetics

Azioni biochim/fisiol

Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.

Stato fisico

Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.

Risultati analitici

The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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K A Crutcher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(6), 2540-2550 (1993-06-01)
A two-site ELISA and a bioassay were used to detect NGF-like activity in human brain tissue. Both assays detected mouse NGF and recombinant human NGF with approximately equal sensitivity, whereas the antibodies showed little cross-reactivity with the recombinant human proteins
Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
Park JC, et al.
Journal of Korean Neurosurgical Society, 61(4), 441-441 (2018)
Mahmoud Aarabi et al.
Fertility and sterility, 102(2), 440-447 (2014-06-09)
To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. Prospective clinical and laboratory study. University-based laboratory and
S Korsching
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2739-2748 (1993-07-01)
The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski MH, et al.
Nature Medicine, 11(5), 551-551 (2005)
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