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MAK034

Sigma-Aldrich

Coenzyme A (CoA) Assay Kit

sufficient for 100 colorimetric or fluorometric tests

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About This Item

Codice UNSPSC:
12161503
NACRES:
NA.84

impiego

sufficient for 100 colorimetric or fluorometric tests

Metodo di rivelazione

colorimetric
fluorometric

Gruppo funzionale

phospholipid

Malattie correlate

endocrinological disorders, diabetes; cancer

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Descrizione generale

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP (adenosine triphosphate). CoA plays important roles in many metabolic pathways, including the Tricarboxylic Acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example Acetyl-CoA, are critical intermediates in many metabolic reactions, particularly fatty acid and carbohydrate metabolism. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

Applicazioni

Coenzyme A (CoA) Assay Kit has been used to measure CoA levels.

Caratteristiche e vantaggi

Compatible with high-throughput handling systems.

Compatibilità

Suitable for the measurement of Coenzyme A (CoA) in a variety of biological samples including cell and tissue lysates

Principio

The Coenzyme A Assay kit is an easy and convenient assay to measure the CoA level in a variety of biological samples. CoA concentration is determined by an enzymatic assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535 nm/λem = 587 nm) product, proportional to the CoA present. Typical sensitivities of detection for this kit are 0.1-10 nmol of CoA.

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H319,H334

Classi di pericolo

Eye Irrit. 2 - Resp. Sens. 1

Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

188.6 °F - closed cup

Punto d’infiammabilità (°C)

87 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Acyl-coenzyme A Synthetase from Pseudomonas sp.

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.
Current Opinion in Cell Biology, 33, 125-131 (2015)
ATP-citrate lyase: a key player in cancer metabolism.
Zaidi N, et al.
Cancer Research (2012)
The subcellular localization of acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Proceedings of the National Academy of Sciences of the USA, 97(4), 1444-1449 (2000)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Science, 291(5513), 2613-2616 (2001)
Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Rosen B C, et al.
Antimicrobial Agents and Chemotherapy, AAC-02130 (2016)
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